Perry, 50, expressed his enthusiasm to finally joining the social media site in his first post Friday.
"This is how thrilled I am to finally be on Instagram," he wrote, along with a GIF of his "Friends" character Chandler Bing dancing up and down. "So, here we go..."
Since launching his account on Thursday, the actor has already amassed more than 3 million followers.
Among those wishing Perry a warm welcome to the site are his former "Friends" co-stars, Jennifer Aniston and Lisa Kudrow.
"I'm shocked Matty is the last to join Instagram," wrote Aniston, who broke the Guinness World Record for fastest time to reach one million followers when she joined the app in October. "considering he was a uh... umm....oh crap... Oh! A computer processing TRANSPONSTER."
Along with her message, Aniston shared a "Friends" clip of her character Rachel Green and Courtney Cox's Monica Geller struggling to remember what Chandler does for a living.
On Thursday, Lisa Kudrow, who played Phoebe Buffay on the show, shared a vintage picture of herself with Perry.
"Finally!!!" she wrote. "Yay!! Can’t believe my eyes MY EYES Welcome to Instagram"